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This double-blind, randomized, 12-week study enrolled 50 patients with clinical and or genotypic diagnosis of HoFH, with or without concomitant LDL apheresis, already receiving atorvastatin or simvastatin 40 mg. Reduction of serum cholesterol with sitostanol-ester margarine in mildly hypercholesterolemic population. Reduce elevated total-C and LDL-C in patients with homozygous familial zetia effects hypercholesterolemia HoFH in combination with atorvastatin or simvastatin.